Page 8 - 66 thorax49-55_opt
P. 8
Gastro-oesophageal Reflux Disease 317
Key Summary Points
1. Gastro-oesophageal reflux is common in newborns and not 3. Laparoscopic or open fundoplication is the operative
necessarily related to disease pathology. Gastro-oesophageal procedure of choice, with a relatively good outcome,
reflux disease is more common in neurologically impaired especially in neurologically normal children. There is a higher
children and those with congenital abnormalities of the upper incidence of complications and recurrences in neurologically
GI tract. impaired children.
2. Conservative and medical therapies are the mainstay
of management, and surgery is reserved for those with
complications and the need for ongoing maximal medical
treatment.
References
1. Sonnenberg A, El Serag HB. Clinical epidemiology and natural 16. Rosen R, Fritz J, Nurko A, Simon D, Nurko S. Lipid-laden
history of gastroesophageal reflux disease. Yale J Biol Med 1999; macrophage index is not an indicator of gastroesophageal
Title Clinical outcome after open and laparoscopic Nissen 72(2–3):81–92. reflux-related respiratory disease in children. Pediatrics 2008;
fundoplication in children: randomised controlled trial 121(4):e879–e884.
2. Mason RJ, Bremner CG. The columnar-lined (Barrett’s)
Authors McHoney M, Eaton S, Drake DP, Kiely EM, Curry J, Spitz L, oesophagus in black patients. S Afr J Surg 1998; 36(2):61–62. 17. Orenstein SR, Magill HL, Brooks P. Thickening of infant
Pierro A feedings for therapy of gastroesophageal reflux. J Pediatr 1987;
3. Segal I. The gastro-oesophageal reflux disease complex in sub-
Institution Great Ormond Street Hospital for Children, London, UK 110(2):181–186.
Saharan Africa. Eur J Cancer Prev 2001; 10(3):209–212.
Reference Abstract Canadian Association of Pediatric Surgery 18. Wenzl TG, Schneider S, Scheele F, et al. Effects of thickened
Conference, October 2004 4. Di Lorenzo C, Piepsz A, Ham H, Cadranel S. Gastric emptying with feeding on gastroesophageal reflux in infants: a placebo-
gastro-oesophageal reflux. Arch Dis Child 1987; 62(5):449–453.
Problem There have been no randomised controlled studies comparing controlled crossover study using intraluminal impedance.
the outcome between open and laparoscopic fundoplication 5. Magista AM, Indrio F, Baldassarre M, et al. Multichannel Pediatrics 2003; 111(4 Pt 1):e355–e359.
in children. The aim of this study was to compare the clinical intraluminal impedance to detect relationship between 19. Corvaglia L, Ferlini M, Rotatori R, et al. Starch thickening of
outcome in children undergoing Nissen fundoplication who gastroesophageal reflux and apnoea of prematurity. Dig Liver Dis human milk is ineffective in reducing the gastroesophageal
were randomised to open surgery or laparoscopy. 2007; 39(3):216–221. reflux in preterm infants: a crossover study using intraluminal
Intervention Randomised to open and laparoscopic Nissen fundoplication. 6. Rosen R, Nurko S. The importance of multichannel intraluminal impedance. J Pediatr 2006; 148(2):265–268.
impedance in the evaluation of children with persistent respiratory
Comparison/ Randomised control trial. symptoms. Am J Gastroenterol 2004; 99(12):2452–2458. 20. Chao HC, Vandenplas Y. Comparison of the effect of a
control cornstarch thickened formula and strengthened regular formula
(quality of 7. Rode H, Millar AJ, Brown RA, Cywes S. Reflux strictures of the on regurgitation, gastric emptying and weight gain in infantile
evidence) esophagus in children. J Pediatr Surg 1992; 27(4):462–465. regurgitation. Dis Esophagus 2007; 20(2):155–160.
Outcome Twenty patients in the open and 19 patients in the 8. Fayed SB, Aref MI, Fathy HM, et al. Prevalence of celiac disease, 21. Chao HC, Vandenplas Y. Effect of cereal-thickened formula and
effect laparoscopic group. Median time to establish full feeds was Helicobacter pylori and gastroesophageal reflux in patients with upright positioning on regurgitation, gastric emptying, and weight
2 days in both groups. Median hospital stay was 4.5 days refractory iron deficiency anemia. J Trop Pediatr 2008; 54(1):43– gain in infants with regurgitation. Nutrition 2007; 23(1):23–28.
in the open group versus 5 days in the laparoscopic group, 53. 22. Horvath A, Dziechciarz P, Szajewska H. The effect of thickened-
with no significant difference between groups. There was
no significant difference in morphine requirements, although 9. Ahmed HH, Mudawi HM, Fedail SS. Gastro-oesophageal reflux feed interventions on gastroesophageal reflux in infants:
pain scores fell significantly faster in the laparoscopy group. disease in Sudan: a clinical endoscopic and histopathological systematic review and meta-analysis of randomized, controlled
Incidence of dysphagia, recurrence of reflux, and need for study. Trop Gastroenterol 2004; 25(3):135–138. trials. Pediatrics 2008; 122(6):e1268–e1277.
redo fundoplication were not significantly different between 10. El Serag HB, Gilger MA, Shub MD, Richardson P, Bancroft J. 23. Corvaglia L, Rotatori R, Ferlini M, et al. The effect of body
groups. At the time of follow-up, the incidence of retching was The prevalence of suspected Barrett’s esophagus in children and positioning on gastroesophageal reflux in premature infants:
higher after open surgery (56%) versus laparoscopy (6%; p = adolescents: a multicenter endoscopic study. Gastrointest Endosc evaluation by combined impedance and pH monitoring. J Pediatr
0.003).
2006; 64(5):671–675. 2007; 151(6):591–596.
Historical This randomised trial demonstrated equal efficacy between
significance/ laparoscopic and open fundoplication in children. 11. Johnson LF, Demeester TR. Twenty-four-hour pH monitoring of 24. van Wijk MP, Benninga MA, Dent J, et al. Effect of body position
comments the distal esophagus. A quantitative measure of gastroesophageal changes on postprandial gastroesophageal reflux and gastric
reflux. Am J Gastroenterol 1974; 62(4):325–332. emptying in the healthy premature neonate. J Pediatr 2007;
151(6):585–590.
12. Da Dalt L, Mazzoleni S, Montini G, Donzelli F, Zacchello F.
Diagnostic accuracy of pH monitoring in gastro-oesophageal 25. Cucchiara S, Minella R, Iervolino C, et al. Omeprazole and high
reflux. Arch Dis Child 1989; 64(10):1421–1426. dose ranitidine in the treatment of refractory reflux oesophagitis.
Arch Dis Child 1993; 69(6):655–659.
13. Tolia V, Kauffman RE. Comparison of evaluation of
gastroesophageal reflux in infants using different feedings during 26. Hassall E, Israel D, Shepherd R, et al. Omeprazole for treatment
intraesophageal pH monitoring. J Pediatr Gastroenterol Nutr 1990; of chronic erosive esophagitis in children: a multicenter study of
10(4):426–429. efficacy, safety, tolerability and dose requirements. International
Pediatric Omeprazole Study Group. J Pediatr 2000; 137(6):800–
14. Loots CM, Benninga MA, Davidson GP, Omari TI. Addition of pH-
impedance monitoring to standard pH monitoring increases the 807.
yield of symptom association analysis in infants and children with 27. Cezard JP. Managing gastro-oesophageal reflux disease in
gastroesophageal reflux. J Pediatr 2009; 154(2):248–252. children. Digestion 2004; 69 Suppl 1:3–8.
15. van Wijk MP, Benninga MA, Omari TI. Role of the multichannel 28. Pritchard DS, Baber N, Stephenson T. Should domperidone be
intraluminal impedance technique in infants and children. J Pediatr used for the treatment of gastro-oesophageal reflux in children?
Gastroenterol Nutr 2009; 48(1):2–12. Systematic review of randomized controlled trials in children aged
1 month to 11 years old. Br J Clin Pharmacol 2005; 59(6):725–729.