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Gastro-oesophageal Reflux Disease  317


                                                    Key Summary Points
             1.  Gastro-oesophageal reflux is common in newborns and not   3.  Laparoscopic or open fundoplication is the operative
                necessarily related to disease pathology. Gastro-oesophageal   procedure of choice, with a relatively good outcome,
                reflux disease is more common in neurologically impaired   especially in neurologically normal children. There is a higher
                children and those with congenital abnormalities of the upper   incidence of complications and recurrences in neurologically
                GI tract.                                           impaired children.
             2.  Conservative and medical therapies are the mainstay
                of management, and surgery is reserved for those with
                complications and the need for ongoing maximal medical
                treatment.




                                                         References

             1.   Sonnenberg A, El Serag HB. Clinical epidemiology and natural   16.  Rosen R, Fritz J, Nurko A, Simon D, Nurko S. Lipid-laden
                 history of gastroesophageal reflux disease. Yale J Biol Med 1999;   macrophage index is not an indicator of gastroesophageal
 Title  Clinical outcome after open and laparoscopic Nissen   72(2–3):81–92.  reflux-related respiratory disease in children. Pediatrics 2008;
 fundoplication in children: randomised controlled trial            121(4):e879–e884.
             2.   Mason RJ, Bremner CG. The columnar-lined (Barrett’s)
 Authors  McHoney M, Eaton S, Drake DP, Kiely EM, Curry J, Spitz L,   oesophagus in black patients. S Afr J Surg 1998; 36(2):61–62.  17.  Orenstein SR, Magill HL, Brooks P. Thickening of infant
 Pierro A                                                           feedings for therapy of gastroesophageal reflux. J Pediatr 1987;
             3.   Segal I. The gastro-oesophageal reflux disease complex in sub-
 Institution  Great Ormond Street Hospital for Children, London, UK  110(2):181–186.
                 Saharan Africa. Eur J Cancer Prev 2001; 10(3):209–212.
 Reference  Abstract Canadian Association of Pediatric Surgery   18.  Wenzl TG, Schneider S, Scheele F, et al. Effects of thickened
 Conference, October 2004  4.   Di Lorenzo C, Piepsz A, Ham H, Cadranel S. Gastric emptying with   feeding on gastroesophageal reflux in infants: a placebo-
                 gastro-oesophageal reflux. Arch Dis Child 1987; 62(5):449–453.
 Problem  There have been no randomised controlled studies comparing   controlled crossover study using intraluminal impedance.
 the outcome between open and laparoscopic fundoplication   5.   Magista AM, Indrio F, Baldassarre M, et al. Multichannel   Pediatrics 2003; 111(4 Pt 1):e355–e359.
 in children. The aim of this study was to compare the clinical   intraluminal impedance to detect relationship between   19.  Corvaglia L, Ferlini M, Rotatori R, et al. Starch thickening of
 outcome in children undergoing Nissen fundoplication who   gastroesophageal reflux and apnoea of prematurity. Dig Liver Dis   human milk is ineffective in reducing the gastroesophageal
 were randomised to open surgery or laparoscopy.  2007; 39(3):216–221.  reflux in preterm infants: a crossover study using intraluminal
 Intervention  Randomised to open and laparoscopic Nissen fundoplication.  6.   Rosen R, Nurko S. The importance of multichannel intraluminal   impedance. J Pediatr 2006; 148(2):265–268.
                 impedance in the evaluation of children with persistent respiratory
 Comparison/  Randomised control trial.  symptoms. Am J Gastroenterol 2004; 99(12):2452–2458.  20.  Chao HC, Vandenplas Y. Comparison of the effect of a
 control                                                            cornstarch thickened formula and strengthened regular formula
 (quality of   7.   Rode H, Millar AJ, Brown RA, Cywes S. Reflux strictures of the   on regurgitation, gastric emptying and weight gain in infantile
 evidence)       esophagus in children. J Pediatr Surg 1992; 27(4):462–465.  regurgitation. Dis Esophagus 2007; 20(2):155–160.
 Outcome   Twenty patients in the open and 19 patients in the   8.   Fayed SB, Aref MI, Fathy HM, et al. Prevalence of celiac disease,   21.  Chao HC, Vandenplas Y. Effect of cereal-thickened formula and
 effect  laparoscopic group. Median time to establish full feeds was   Helicobacter pylori and gastroesophageal reflux in patients with   upright positioning on regurgitation, gastric emptying, and weight
 2 days in both groups. Median hospital stay was 4.5 days   refractory iron deficiency anemia. J Trop Pediatr 2008; 54(1):43–  gain in infants with regurgitation. Nutrition 2007; 23(1):23–28.
 in the open group versus 5 days in the laparoscopic group,   53.  22.  Horvath A, Dziechciarz P, Szajewska H. The effect of thickened-
 with no significant difference between groups. There was
 no significant difference in morphine requirements, although   9.   Ahmed HH, Mudawi HM, Fedail SS. Gastro-oesophageal reflux   feed interventions on gastroesophageal reflux in infants:
 pain scores fell significantly faster in the laparoscopy group.   disease in Sudan: a clinical endoscopic and histopathological   systematic review and meta-analysis of randomized, controlled
 Incidence of dysphagia, recurrence of reflux, and need for   study. Trop Gastroenterol 2004; 25(3):135–138.  trials. Pediatrics 2008; 122(6):e1268–e1277.
 redo fundoplication were not significantly different between   10.  El Serag HB, Gilger MA, Shub MD, Richardson P, Bancroft J.   23.  Corvaglia L, Rotatori R, Ferlini M, et al. The effect of body
 groups. At the time of follow-up, the incidence of retching was   The prevalence of suspected Barrett’s esophagus in children and   positioning on gastroesophageal reflux in premature infants:
 higher after open surgery (56%) versus laparoscopy (6%; p =   adolescents: a multicenter endoscopic study. Gastrointest Endosc   evaluation by combined impedance and pH monitoring. J Pediatr
 0.003).
                 2006; 64(5):671–675.                               2007; 151(6):591–596.
 Historical   This randomised trial demonstrated equal efficacy between
 significance/  laparoscopic and open fundoplication in children.  11.  Johnson LF, Demeester TR. Twenty-four-hour pH monitoring of   24.  van Wijk MP, Benninga MA, Dent J, et al. Effect of body position
 comments        the distal esophagus. A quantitative measure of gastroesophageal   changes on postprandial gastroesophageal reflux and gastric
                 reflux. Am J Gastroenterol 1974; 62(4):325–332.    emptying in the healthy premature neonate. J Pediatr 2007;
                                                                    151(6):585–590.
             12.  Da Dalt L, Mazzoleni S, Montini G, Donzelli F, Zacchello F.
                 Diagnostic accuracy of pH monitoring in gastro-oesophageal   25.  Cucchiara S, Minella R, Iervolino C, et al. Omeprazole and high
                 reflux. Arch Dis Child 1989; 64(10):1421–1426.     dose ranitidine in the treatment of refractory reflux oesophagitis.
                                                                    Arch Dis Child 1993; 69(6):655–659.
             13.  Tolia V, Kauffman RE. Comparison of evaluation of
                 gastroesophageal reflux in infants using different feedings during   26.  Hassall E, Israel D, Shepherd R, et al. Omeprazole for treatment
                 intraesophageal pH monitoring. J Pediatr Gastroenterol Nutr 1990;   of chronic erosive esophagitis in children: a multicenter study of
                 10(4):426–429.                                     efficacy, safety, tolerability and dose requirements. International
                                                                    Pediatric Omeprazole Study Group. J Pediatr 2000; 137(6):800–
             14.  Loots CM, Benninga MA, Davidson GP, Omari TI. Addition of pH-
                 impedance monitoring to standard pH monitoring increases the   807.
                 yield of symptom association analysis in infants and children with   27.  Cezard JP. Managing gastro-oesophageal reflux disease in
                 gastroesophageal reflux. J Pediatr 2009; 154(2):248–252.  children. Digestion 2004; 69 Suppl 1:3–8.
             15.  van Wijk MP, Benninga MA, Omari TI. Role of the multichannel   28.  Pritchard DS, Baber N, Stephenson T. Should domperidone be
                 intraluminal impedance technique in infants and children. J Pediatr   used for the treatment of gastro-oesophageal reflux in children?
                 Gastroenterol Nutr 2009; 48(1):2–12.               Systematic review of randomized controlled trials in children aged
                                                                    1 month to 11 years old. Br J Clin Pharmacol 2005; 59(6):725–729.
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