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Figure 2. The reduced GLP-1 response to food in T2DM, compared with normal patients.
The meal was started at time zero and finished in the 10- to 15-min period. Adapted
from Toft-Nielsen, et al. 2001. 7
Figure 3. Integrated responses of ‘total’ GLP to oral glucose or mixed meals based on
individual studies (a) reporting integrated incremental ‘total’ GLP-1 responses in patients
with T2DM and an appropriate control group (weight-matched, non-diabetic participants)
and using non-specific assays that measured intact and DPP-4-degraded forms of GLP-1. 9
(b) Meta-analysis of studies dealing with secretion and providing incremental responses
of GLP-1 in healthy subjects and patients with T2DM after an oral glucose tolerance test
and/or after a standardised mixed meal.
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