Page 8 - 20dynamics of cancer

Contents

1 Introduction 1

1.1 Aims 2
1.2 How to Read 4
1.3 Chapter Summaries 5

PART I: BACKGROUND

2 Age of Cancer Incidence 17

2.1 Incidence and Acceleration 19
2.2 Different Cancers 20
2.3 Childhood Cancers 23
2.4 Inheritance 25
2.5 Carcinogens 29
2.6 Sex Differences 32
2.7 Summary 35

3 Multistage Progression 36
3.1 Terminology 37
3.2 What Is Multistage Progression? 38
3.3 Multistage Progression in
Colorectal Cancer 39
3.4 Alternative Pathways to
Colorectal Cancer 43
3.5 Changes during Progression 49
3.6 What Physical Changes Drive
Progression? 50
3.7 What Processes Change during
Progression? 51
3.8 How Do Changes Accumulate in
Cell Lineages? 55
3.9 Summary 58