Page 11 - 20dynamics of cancer

x CONTENTS

PART III: EVOLUTION

11 Inheritance 213

11.1 Genetic Variants Affect
Progression and Incidence 214
11.2 Progression and Incidence Affect
Genetic Variation 234
11.3 Few Common or Many Rare
Variants? 243
11.4 Summary 250

12 Stem Cells: Tissue Renewal 251
12.1 Background 252
12.2 Stem-Transit Program of
Renewal 253
12.3 Symmetric versus Asymmetric
Stem Cell Divisions 264
12.4 Asymmetric Mitoses and the
Stem Line Mutation Rate 265
12.5 Tissue Compartments and
Repression of Competition 269
12.6 Summary 270

13 Stem Cells: Population Genetics 271
13.1 Mutations during Development 272
13.2 Stem-Transit Design 280
13.3 Symmetric versus Asymmetric
Mitoses 283
13.4 Summary 285

14 Cell Lineage History 286
14.1 Reconstructing Cellular
Phylogeny 287
14.2 Demography of Progression 295
14.3 Somatic Mosaicism 304
14.4 Summary 308