Page 10 - 20dynamics of cancer

CONTENTS ix

6.5 Time-Varying Transition Rates 109
6.6 Summary 114

7 Theory II 115

7.1 Multiple Pathways of Progression 116
7.2 Discrete Genetic Heterogeneity 120
7.3 Continuous Genetic and
Environmental Heterogeneity 129
7.4 Weibull and Gompertz Models 136
7.5 Weibull Analysis of Carcinogen
Dose-Response Curves 139
7.6 Summary 142

8 Genetics of Progression 143
8.1 Comparison between Genotypes
in Human Populations 144
8.2 Comparison between Genotypes
in Laboratory Populations 154
8.3 Polygenic Heterogeneity 160
8.4 Summary 164

9 Carcinogens 165

9.1 Carcinogen Dose-Response 166
9.2 Cessation of Carcinogen
Exposure 180
9.3 Mechanistic Hypotheses and
Comparative Tests 190
9.4 Summary 201

10 Aging 202
10.1 Leading Causes of Death 203
10.2 Multistage Hypotheses 206
10.3 Reliability Models 207
10.4 Conclusions 209
10.5 Summary 209