Page 98 - Cardiac testing for coronary artery disease in potential kidney transplant recipients

Table 2. Characteristics of included studies (Continued)

Sharma UK 125 39 42 91 64 70 27 14 9 75
2005

FN: false negative; FP: false positive; NA: not available; TN: total negative; TP: total positive
* Study unable to contribute data to meta-analysis as it reported results per coronary vessel, and not per patient

Table 3. Comparison of summary estimates of test performance for dobutamine stress echocardiography (DSE) and myocardial
perfusion scintigraphy (MPS)

Test Studies (N) Sensitivity (95% Specificity (95% Diagnostic odds AUC P value for difference in accu-
CI) CI) ratio (95% CI) racy*

Overall results: including all studies

MPS 9 0.74 0.70 6.69 0.78 0.02
(0.54 to 0.87) (0.51 to 0.84) (2.35 to 19.03)

DSE 13 0.79 0.89 29.98 0.91
(0.67 to 0.88) (0.81 to 0.94) (12.17 to 73.89)

Only including studies where reference standard threshold ≥ 70% coronary artery stenosis on coronary angiography
MPS 7 0.67 0.77 6.70 0.78 0.09
(0.48 to 0.82) (0.61 to 0.88) (1.84 to 24.41)

DSE 9 0.76 0.88 23.01 0.90
(0.60 to 0.87) (0.78 to 0.94) (8.08 to 65.51)

Only including studies where partial verification was avoided

MPS 8 0.68 0.75 6.45 0.78 0.03
(0.51 to 0.81) (0.60 to 0.86) (2.12 to 19.64)
DSE 9 0.80 0.89 34.28 0.92
(0.64 to 0.90) (0.79 to 0.95) (11.10 to 105.93)

Only including studies which avoided partial verification and had reference standard threshold ≥ 70% coronary artery stenosis
on coronary angiography

MPS 7 0.67 0.77 6.70 0.78 0.09
(0.48 to 0.82) (0.61 to 0.88) (1.84 to 24.41)
DSE 8 0.78 0.88 25.22 0.90
(0.59 to 0.89) (0.76 to 0.94) (7.68 to 82.80)

AUC: area under the curve; CI: confidence interval; DSE: dobutamine stress echocardiography; MPS: myocardial perfusion scintigraphy

Cardiac testing for coronary artery disease in potential kidney transplant recipients (Review) 96
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