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Table 7. Eligibility criteria for enrollment in protocols with palliative intent in chronological order of starting enrollment year

 Center, Country   Term used   Age (yr)   PSA   Gleason   # biopsy   Imaging   Stage   Behavioral indication
 [Pubmed ID]   (ng/mL)   score   cores /%                  (other than patients’
 Enrollment years   cores                                  choice or preference)
 Howard University   EM /WW   –   –   –   –   –   Stage A and B   –
 College of
 Medicine, US 138
 [1600492]

 1967-1989
 Orebro Medical   Deferred   Any (all patients >75   –   –   –   –   T0-T2   –
 Center, Sweden 139    treatment   were not given any
 [7933233]   initial treatment from
    1978-79)
 1977-1984
 Northern   WW   –   –   –   –   Normal   71% T1-2 and     –
 Stockholm region,    bone scan     29% with T3
 Sweden 140
 [17467883]

 1978-1982
 Freeman Hospital,   Deferred   –   –   –   –   –   –      Patients without
 UK 141    treatment                                       symptoms after initial
 [3191340]                                                 outflow tract surgery or
                                                           biopsy
 1978-1985
 Western General   Deferred   –   –   –   –   –   incidental   –
 Hospital, UK 142    treatment      (T0/stage A) or
 [8343901]                          localized *T1/stage
                                    B1/B2)
 1978-1990























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