Page 53 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

collects data from 40 urology practices in the United States (34 community based, 3
d
Veterans Administration [VA])-based and 3 academic center based). Although
CaPSURE patients are broadly representative of prostate cancer diagnosed in the
community, patient selection is not based on a formal population sampling scheme.
• The NCDB is an oncology outcomes database encompassing more than 1,500 cancer
programs in the U.S. (including Puerto Rico) accredited by the Commission on Cancer of
e
the American College of Surgeons and the American Cancer Society.
• Other databases utilized by the primary studies were the Patterns of Care study
(sponsored by NCI and based on sampling participants through SEER) and the Los
Angeles County/University of Southern California (LAC/USC) Cancer Surveillance
Program (which is now a component registry of SEER).

In addition to the above databases, several studies obtained prostate cancer mortality data
f rom the National Center for Health Statistics (NCHS) of the Centers for Disease Control and
f
P revention (CDC), the U.S. principal health agency for vital statistics.
th
th
Included studies had large sample sizes (median sample size = 54,670 patients; 25 -75
p ercentile 11,161-138,387), were published between 1990 and 2011, and analyzed data from
1 969 to 2008. Figure 3 presents the years covered by each primary study and the databases used.
A ppendix Tables C1.1-C1.14 present additional information about each of the studies relevant to
K ey Question 1.
We organized the 79 studies into four groups, each of which is discussed in the following
s ections:
1. studies investigating trends in prostate cancer incidence
2. studies investigating trends in prostate cancer mortality or survival
3. studies investigating patient-, tumor-, or system-level characteristics at prostate cancer
diagnosis, and
4. studies presenting information in treatment trends over time

d See http://urology.ucsf.edu/clinicalres/CRuroOnc_gceps_capsure.html; last accessed September 30, 2011.
e See http://www.facs.org/cancer/ncdb/index.html; last accessed September 30, 2011.
f See http://www.cdc.gov/nchs/; last accessed September 30, 2011.

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