Page 468 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer
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Appendix Table C4.1. Descriptive characteristics of the randomized controlled trials and comparative cohort studies considered
relevant to KQ4 (continued)
Author, Year Study name Comparison Study Sample Inclusion criteria Population description: Quality
[Pubmed ID] /Database duration size (total) Age Comments
PSA (ng/mL)
Study design Tumor grade
Stage
Berge 231 SEER- WW vs. RP 1991-92 12,711 cT1-2 or pT1-3, age ≥65, Median age: WW, 77; RP, 70; C
2007 Medicare vs. RT vs. continuously enrolled on RT, 74
a
17178188 ADT 5 yr Medicare for the entire study
period. Excluded patients PSA: NR
Retrospective enrolled in an HMO, those with
cohort primary treatment discrepancy Grade: WW, well dif., 40.2%;
between SEER and Medicare moderately dif., 40.8%; poorly
data, those who died before the dif., 10.3%; undiff, 0.6%;
end of the study period, patients unknown, 8.2%. RP, well dif.,
with metastatic disease, and 10.2%; moderately dif., 67.6%;
those with tumors clinically poorly dif., 20.5%; undiff, 0.5%;
classified as extension through unknown, 1.2%. RT, well dif.,
capsule or with positive lymph 20.5%; moderately dif., 58.1%;
nodes (only for the non-RP poorly dif., 15.7%; undiff, 0.6%;
groups). unknown, 5.0%.
Patients with pT3 tumors were Stage: WW, In situ, 0.9%; T1/2,
included only in the surgical arm 99.1; pT3, 0%. RP, In situ, 0.1;
to account for the lack of T1/2, 54.6; pT3, 45.4%. RT, In
pathologic staging in patients situ, 0%; T1/2, 100%; pT3, 0%.
receiving other treatments.
Elliott 218 CaPSURE (RP, Median 6597 Newly diagnosed with prostate Age: <60 yr, 25%; 60-59, 40%; B
2007 RP+EBRT, 2.7 yr cancer between 1995 and 2006 ≥70 yr, 35%
17570425 cryotherapy, (range 3 with complete diagnostic and
BT, days to treatment clinical data available, PSA: ≤4, 14%; 4.1-10.0, 62%;
Retrospective BT+EBRT, 10.9 yr) and without a history of urethral 10.1-20.0, 16%; >20, 8%
cohort EBRT, or stricture
hormones) Gleason score: 2-6, 65%; 7,
vs. WW 26%; 8-10, 9%
Stage: T1, 53%; T2, 45%; T3a,
2%
a We did not extract data from the group of patients receiving primary ADT as the only initial therapy.
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