Page 353 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C2.1. Eligibility criteria, follow-up protocols, triggers for intervention and definition of progression in cohorts of active
surveillance/ watchful waiting/other observational management strategies (continued)

Center, Country Eligibility criteria Followup or monitoring protocol Triggers for intervention/ Definition of
[PMID] active therapy progression
Enrollment year
Johns Hopkins, PSA density Semiannual PSA and DRE; annual extended 12-core biopsy Annual surveillance biopsy: Progression =
US 113 ≤0.15 Gleason ≥7; or Gleason unfavorable
[20439642] ng/mL/cm3; pattern 4 or 5; or >2 cores biopsy 249
T1C; 12-core cancer positive; or single
1994-2008 biopsy: Gleason core >50% cancer.
≤6; no Patient request or
Gleason pattern encouraged to seek
≥4; ≤2 cores curative treatment if
cancer positive; perineural invasion on
137
≤50% cancer biopsy.
in any single PSA kinetics not used as a
core (also trigger for intervention.
included some
men who did
not meet these
criteria due to
personal
preference or
comorbidity)

C-94