Page 354 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C2.1. Eligibility criteria, follow-up protocols, triggers for intervention and definition of progression in cohorts of active
surveillance/ watchful waiting/other observational management strategies (continued)

Center, Country Eligibility criteria Followup or monitoring protocol Triggers for intervention/ Definition of
[PMID] active therapy progression
Enrollment year
st
Kagawa Medical Japanese patients PSA doubling time based on 1 PSA >1 mo after biopsy. ≥3 NR NR
Univ., Japan 153 with values at intervals ≥1 mo apart for >6 mo. Exponential slope
[10765093] nonpalpable fitted by regression.
prostate cancer,
1990-1998 detected by
elevated PSA.
Diagnosed
histopathologic
ally by TRUS-
guided six
sextant biopsy:
(1) Gleason
score ≤6; (2)
1-2 positive
cores per 6
sextant cores;
and (3) ≤50%
involvement of
any positive
core

C-95