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Appendix C: Economic evaluation of testing strategies for hyperbilirubinaemia





                         Table C.3  TSB resources and costs
                         Resources       Unit cost  Source                       Notes
                         Clinical nurse   £69.00   PSSRU (2008) 239              It is assumed that it would take
                         specialist              (www.pssru.ac.uk/pdf/uc/uc2008/uc200 10 minutes to perform this test
                                                 8.pdf)
                         Venous blood test  £7.00   GDG estimate                 One per test
                         Gloves          £0.06   medisave.co.uk, accessed 16 July 2009  £6.27 per 100; one pair per test


                         Table C.4  TCB resources and costs
                         Resources       Unit cost  Source                       Notes
                         Clinical nurse   £69.00   PSSRU (2008) 239              It is assumed that it would take
                         specialist                                              1 minute to perform this test
                         TCB meter       £3,400   Manufacturer, JM-103           No consumables required
                                         £3,600   Manufacturer, BiliChek

                         Calibration tips    £5.50   Manufacturer, BiliChek
                         TSB             £18.56   Marginal cost of TSB (see Table C.3)   It is estimated that 25% of TCB
                                                                                 tests would be positive leading
                                                                                 to a TSB

                         The purchase of medical equipment, TCB meters in this case, carries an opportunity cost that
                         differs from operating costs such as labour and consumables in certain respects. The purchase of
                         TCB meters involves an upfront payment before use. However, that cost is fixed as it does not
                         vary with the quantity of treatment provided. The equipment can often be used over a number
                         of years before it needs to be replaced.
                         The equipment costs have two facets:
                         •   opportunity cost – the money spent on the equipment could have been invested in some
                           other venture yielding positive benefits; it is calculated by applying an interest rate to the sum
                           invested in the equipment
                         •   depreciation cost – the equipment has a certain lifespan and depreciates over time;
                           eventually, the equipment has to be replaced.
                         In economic evaluation, the usual practice is to annuitise the initial capital outlay over the
                         expected life of the equipment to give an ‘equivalent annual cost’. Calculating the equivalent
                         annual cost means making an allowance for the differential timing of costs, using discounting.
                         The formula for calculating the equivalent annual cost is given below:

                             K    1 S   r  n
                         E  
                                  
                                A,nr
                         where:
                         E = equivalent annual cost
                         K = purchase price of equipment
                         S = resale value
                         r = discount (interest rate)
                         n = equipment lifespan
                         A(n,r) = annuity factor* (n years at interest rate r )
                         To calculate the equivalent annual cost we have assumed that the meters last 5 years and have
                         no resale value. However, the total annual equivalent cost would depend on the actual number
                         of meters that were necessary to deliver the strategy. This is not known and service delivery is
                         not generally part of the remit of  NICE guidelines. Therefore, the results are presented as a
                         threshold  analysis,  with  the  threshold  being  the  number  of  meters  at  which  the  TSB  strategy
                         (Strategy 2) would be equivalent in cost to the TCB strategy (Strategy 3).

              *  An annuity factor converts a present valueinto an annuity, a series of equal annual payments.

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