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Summary of recommendations

2.4 Summary of research recommendations

Assessment for dehydration and shock (Chapter 4)
In children with gastroenteritis, what is the predictive value of clinical symptoms and signs
in assessing the severity of dehydration, using post-rehydration weight gain as the reference
standard, in primary and secondary care settings?

Fluid management (Chapter 5)
In children who do not tolerate oral rehydration therapy, is ORS solution administration via
nasogastric tube cost-effective, safe and acceptable in treating dehydration compared with
intravenous fluid therapy?
In children who require intravenous fluid therapy for the treatment of dehydration, is rapid
rehydration safe and cost-effective compared with the common practice of rehydration over
24 hours?

Other therapies (Chapter 8)
In children with persistent vomiting caused by gastroenteritis, is oral ondansetron cost-effective
and safe compared with placebo therapy?
Is racecadotril (an enkephalinase inhibitor) cost-effective and safe in the treatment of gastroenteritis
in children compared with a placebo?
Are probiotics effective and safe compared with a placebo in the treatment of children with
gastroenteritis in the UK? Which specific probiotic is most effective and in what specific treatment
regimen?

2.5 Flow pathway for fluid management

The fluid management flow pathway overleaf is reproduced (with minor amendment of the cross-
references) from the NICE Quick Reference Guide version of this guideline (www.nice.org.uk/
CG84quickrefguide).

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