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The primary economic focus in this guideline was on alternative fluid management therapy for
children with dehydration. A decision-analytic model was developed to compare ORT with IVT.
A simple economic analysis was also carried out in order to help guide recommendations on
the use of ondansetron in vomiting children. The results of both analyses are summarised in the
guideline text and a detailed description of the models has been included in Appendices A and
B, respectively.

1.7.4 Forming and grading recommendations

The evidence tables, evidence overviews and summaries for the key clinical questions
being discussed were made available to the GDG before the scheduled GDG meetings, and
GDG members were expected to have read these in advance. For each clinical question,
recommendations were derived using, and explicitly linked to, the evidence that supported
them. Informal consensus methods were used by the GDG to agree evidence statements and
recommendations, including the areas where important clinical questions were identified but
no substantial evidence existed. The process by which the evidence statements informed the
recommendations is summarised in a ‘GDG translation’ section in the relevant evidence review.
Formal consensus methods were used to agree guideline recommendations and select eight key
priorities for implementation.

1.7.5 External review

This guideline has been developed in accordance with the NICE guideline development process.
This has included giving registered stakeholder organisations the opportunity to comment
on the scope of the guideline at the initial stage of development and on the evidence and
recommendations at the concluding stage. In addition, the guideline was peer reviewed.

1.8 Schedule for updating the guideline

Clinical guidelines commissioned by NICE are published with a review date 4 years from date
of publication. Reviewing may begin earlier than 4 years if significant evidence that affects
guideline recommendations is identified sooner. The updated guideline will be available within
2 years of the start of the review process.

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