Page 158 - 80 guidelines for the treatment of malaria_opt
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Guidelines for the treatment of malaria – 2 edition
a7.2 Question:
Is three days of artesunate superior to one day in a combination regime for
uncomplicated P. falciparum malaria?
importance CRITICAL
Is artesunate 3 days superior to artesunate 1 day in a combination regime for treating uncomplicated
Quality VERY LOW
Absolute Not pooled
effect Relative risk (95% CI) RR 0.62
summary of findings no. of patients AS 1 day AS 3 days 382/816 236/818 (46.8%) (28.9%)
considerations
Other None
Imprecision No serious imprecision 3
Indirectness No serious indirectness 2 No serious limitations: allocation concealment was adequate in five of the studies and unclear in the sixth (10). No serious indirectness: five trials recruited both adults and children and one trial recruited children only. No serious imprecision: the upper border of the 95% CI of the poo
Inconsistency EFFICACy: parasitological failure (including re-infections) by day 28 (follow-up 28 days) No serious inconsistency
Limitations No serious 1 limitations
GRADE Table A7.2.1 P. falciparum malaria? Quality assessment Design Randomized trial
144 No. of studies 5 1. 2. 3.
