Page 74 - 78 glossary of hivaids-related terms_opt

Interleukin-2 (IL-2)
A cytokine (protein that regulates immune system activity) that can
increase the production of certain disease-fighting white blood cells.
During HIV infection, IL-2 levels gradually decline. A laboratory-
made version of IL-2 is used to treat some cancers and has been
studied as a way to increase the number of CD4 cells and other
immune system cells in people with HIV.
See Also: Cytokine

Interleukin-7 (IL-7)
A cytokine (protein that regulates immune system activity) produced
in small amounts in bone marrow cells that increases the body’s
I production of certain disease-fighting white blood cells. Laboratory-
produced IL-7 is a drug product that appears to induce HIV
replication in latent, or resting, infected cells. Activation of HIV in
resting cells allows antiretroviral drugs to target HIV in those cells.
See Also: Cytokine

International Maternal Pediatric Adolescent AIDS Clinical Trials
(IMPAACT) Network
A clinical trials network that evaluates treatments for HIV-infected
children and adolescents and also develops new therapeutic ap-
proaches for preventing mother-to-child transmission (MTCT) of HIV.

International Network for Strategic Initiatives in Global HIV
Trials (INSIGHT)
A clinical trials network that evaluates strategies for optimizing
treatment by doing large simple trials in HIV-infected individuals.

Interstitial Nephritis
A kidney disorder caused by inflammation of the small spaces
between parts of the kidney. The condition is a potential side effect
of certain anti-HIV drugs.

Intervention
In medicine, a treatment or action taken to prevent or treat a
disease or to improve health in other ways.

72 HIV/AIDS Glossary