Page 242 - HIV/AIDS Guidelines

Creatinine Clearance Calculation
Male: (140 − age in years) x weight (kg) Female: (140 − age in years) x weight (kg) x 0.85
72 x Serum Creatinine 72 x Serum Creatinine

Child-Pugh Score

Component Points Scored
1 2 3

a
Encephalopathy None Grade 1–2 Grade 3–4
Ascites None Mild or controlled by diuretics Moderate or refractory despite
diuretics

Albumin >3.5 g/dL 2.8–3.5 g/dL <2.8 g/dL
Total bilirubin or <2 mg/dL (<34 μmol/L) 2–3 mg/dL (34 μmol/L to >3 mg/dL (>50 μmol/L)
50 μmol/L)

Modified total bilirubin b <4 mg/dL 4–7 mg/dL >7 mg/dL
Prothrombin time <4 4–6 >6
(seconds prolonged) or
International normalized ratio <1.7 1.7–2.3 >2.3
(INR)
a
Encephalopathy Grades
Grade 1: Mild confusion, anxiety, restlessness, fine tremor, slowed coordination
Grade 2: Drowsiness, disorientation, asterixis
Grade 3: Somnolent but rousable, marked confusion, incomprehensible speech, incontinence, hyperventilation
Grade 4: Coma, decerebrate posturing, flaccidity
b
Modified total bilirubin used for patients who have Gilbert’s syndrome or who are taking indinavir or atazanavir

Child-Pugh Classification Total Child-Pugh Score c

Class A 5–6 points

Class B 7–9 points
Class C >9 points

c
Sum of points for each component

Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents O-17

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