Page 227 - HIV/AIDS Guidelines

Appendix B, Table 1. Characteristics of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) (Last
updated March 27, 2012; last reviewed March 27, 2012) (page 2 of 3)

Dosing
Recommendations
Generic Name Serum/
(abbreviation)/ Formulations (For dosage adjustment Elimination Intracellular Adverse Events
Trade Name in renal or hepatic Half-lives (Also see Table 13)
insufficiency, see
Appendix B, Table 7.)
Emtricitabine Emtriva Emtriva Renal excretion 86% 10 hrs/ • Minimal toxicity
(FTC)/Emtriva • 200-mg hard Capsule: 200 mg once daily >20 hrs • Hyperpigmentation/skin
gelatin capsule Oral solution: 240 mg Dosage adjustment
Also available as (24 mL) once daily in patients with renal discoloration
component of • 10-mg/mL oral insufficiency • Severe acute exacerbation of
fixed-dose solution Take without regard to recommended (See hepatitis may occur in HBV-
combinations: meals Appendix B, Table 7.) coinfected patients who
Atripla Atripla Atripla discontinue FTC.
FTC (FTC 200 mg + 1 tablet at or before
with EFV+TDF EFV 600 mg + bedtime
TDF 300 mg) tablet
Take on an empty stomach
to reduce side effects
Complera Complera Complera
FTC (FTC 200 mg + 1 tablet once daily with a
with RPV+TDF RPV 25 mg + meal
TDF 300 mg) tablet
Truvada Truvada Truvada
FTC with TDF FTC 200 mg + 1 tablet once daily
TDF 300 mg tablet
Lamivudine Epivir Epivir Renal excretion 70% 5–7 hrs/ • Minimal toxicity
(3TC)/ • 150-, 300-mg 150 mg BID or 18–22 hrs • Severe acute exacerbation of
Epivir (generic tablets 300 mg once daily Dosage adjustment hepatitis may occur in HBV-
available) in patients with renal
• 10-mg/mL oral Take without regard to insufficiency coinfected patients who
Also available as solution meals recommended (See discontinue 3TC.
component of Appendix B, Table 7.)
fixed-dose
combinations:
Combivir (generic Combivir Combivir
available) (3TC 150 mg + 1 tablet BID
3TC with ZDV ZDV 300 mg) tablet
Epzicom Epzicom Epzicom
3TC with ABC (3TC 300 mg + 1 tablet once daily
ABC 600 mg) tablet
Trizivir Trizivir Trizivir
3TC with ZDV+ABC (3TC 150 mg + 1 tablet BID
ZDV 300 mg + ABC
300 mg) tablet
Stavudine Zerit Body weight ≥60 kg: Renal excretion 50% 1 hr/ • Peripheral neuropathy
(d4T)/ • 15-, 20-, 30-, 40- 40 mg BID 7.5 hrs • Lipoatrophy
Zerit (generic mg capsules Body weight <60 kg: Dosage adjustment • Pancreatitis
available) in patients with renal • Lactic acidosis/severe
• 1-mg/mL oral 30 mg BID insufficiency hepatomegaly with hepatic
solution recommended (See
Take without regard to meals steatosis (rare but potentially life-
Appendix B, Table 7.) threatening toxicity)
Note: WHO recommends 30
mg BID dosing regardless • Hyperlipidemia
• Insulin resistance/diabetes mellitus
of body weight.
• Rapidly progressive ascending
neuromuscular weakness (rare)
Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents O-2

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