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Appendix H: Evidence tables


            Evidence Table – Assessment Tests
            TSB 255 – 399 micromol/litre


              Bibliographic details   Study type &   Patient characteristics                Results                           Reviewers Comments
                                  Evidence level
              Author: Biddulph J   Study type:    Diagnosis: Jaundice                       Mean bilirubin levels             Small study
                                  Consecutive case-  Criteria: TSB ≥ 256 micromol/litre     TSB: Not reported
              Year: 1974          series          Setting: Hospital
                                                                                            Incidence of ABO incompatibility: 12/50 (24%)
              Country: Papua New   Evidence level: 3   Sample Size: 50
              Guinea                              Mean GA: Not reported                     Rh incompatibility: Not reported
                                                  Mean BW: Not reported
                   95
              Ref ID:                             Gender M/F:29/21                          Incidence of G6PD deficiency: 11/50 (22%)
                                                  Ethnicity: Not reported
                                                  Breastfeeding: 50 (100%)                  Incidence of sepsis: 8/50 (16%)
                                                  Onset of Jaundice: Day 1 - 17
                                                  Duration of jaundice: 26 (52%) < 1 week   Idiopathic: 19/50 (38%)

                                                  Exclusion: None                           Exchange transfusion (n = 11)
                                                                                            Incidence of ABO incompatibility: 4/11 (36.4%)

                                                                                            Incidence of G6PD deficiency: 3/11 (27.3%)

                                                                                            Incidence of sepsis: 2/11 (18.2%)

                                                                                            Idiopathic: 2/11 (18.2%)

              Author: Seidman D   Study type:     Diagnosis: Jaundice                       Mean bilirubin levels             Small study
                                  Case series     Criteria: TSB ≥ 308 micromol/litre        TSB: 335 ± 43 micromol/litre
              Year: 1995                          Setting: Hospital                                                           Subjects had received phototherapy
                                  Evidence level: 3                                           ABO incompatibility: 0/21 (0%)   and were discharged with TSB
              Country: Israel                     Sample Size: 21                                                             > 171 micromol/litre so could qualify
                                                  Mean GA: 39.3 ± 1.2 weeks                 Rh incompatibility: 0/21 (0%)     as persistent jaundice
                   93
              Ref ID:
                                                  Mean BW: 3206 ± 340 gms
                                                  Gender M/F: 15/6                          G6PD deficiency: 2/21 (9.5%)
                                                  Ethnicity: 9 Jew Askenazi, 3 Kurdish, 2 Iraqi and others.     Infection: 0/21 (0%)
                                                  Breastfeeding: 20/21
                                                  Onset of Jaundice: Day 0 - 10             Idiopathic: Not reported

                                                  Exclusion: None
              Author: Effiong C   Study type:     Diagnosis: Jaundice                       Mean bilirubin levels
                                  Case series     Criteria: TSB ≥ 256 micromol/litre        TSB: Not reported
              Year: 1975                          Setting: Hospital
                                  Evidence level: 3                                         ABO incompatibility: 26/125 (20.6%)
              Country: Nigeria                    Sample Size: 125
                                                  Mean GA: Not reported                     Rh incompatibility: 2/125 (1.6%)
                   94
              Ref ID:                             Mean BW: Not reported
                                                  Gender M/F: 70/55                         G6PD deficiency:


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