Page 348 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Evidence Table – Assessment Tests
TSB 255 – 399 micromol/litre

Bibliographic details Study type & Patient characteristics Results Reviewers Comments
Evidence level
Author: Biddulph J Study type: Diagnosis: Jaundice Mean bilirubin levels Small study
Consecutive case- Criteria: TSB ≥ 256 micromol/litre TSB: Not reported
Year: 1974 series Setting: Hospital
Incidence of ABO incompatibility: 12/50 (24%)
Country: Papua New Evidence level: 3 Sample Size: 50
Guinea Mean GA: Not reported Rh incompatibility: Not reported
Mean BW: Not reported
95
Ref ID: Gender M/F:29/21 Incidence of G6PD deficiency: 11/50 (22%)
Ethnicity: Not reported
Breastfeeding: 50 (100%) Incidence of sepsis: 8/50 (16%)
Onset of Jaundice: Day 1 - 17
Duration of jaundice: 26 (52%) < 1 week Idiopathic: 19/50 (38%)

Exclusion: None Exchange transfusion (n = 11)
Incidence of ABO incompatibility: 4/11 (36.4%)

Incidence of G6PD deficiency: 3/11 (27.3%)

Incidence of sepsis: 2/11 (18.2%)

Idiopathic: 2/11 (18.2%)

Author: Seidman D Study type: Diagnosis: Jaundice Mean bilirubin levels Small study
Case series Criteria: TSB ≥ 308 micromol/litre TSB: 335 ± 43 micromol/litre
Year: 1995 Setting: Hospital Subjects had received phototherapy
Evidence level: 3 ABO incompatibility: 0/21 (0%) and were discharged with TSB
Country: Israel Sample Size: 21 > 171 micromol/litre so could qualify
Mean GA: 39.3 ± 1.2 weeks Rh incompatibility: 0/21 (0%) as persistent jaundice
93
Ref ID:
Mean BW: 3206 ± 340 gms
Gender M/F: 15/6 G6PD deficiency: 2/21 (9.5%)
Ethnicity: 9 Jew Askenazi, 3 Kurdish, 2 Iraqi and others. Infection: 0/21 (0%)
Breastfeeding: 20/21
Onset of Jaundice: Day 0 - 10 Idiopathic: Not reported

Exclusion: None
Author: Effiong C Study type: Diagnosis: Jaundice Mean bilirubin levels
Case series Criteria: TSB ≥ 256 micromol/litre TSB: Not reported
Year: 1975 Setting: Hospital
Evidence level: 3 ABO incompatibility: 26/125 (20.6%)
Country: Nigeria Sample Size: 125
Mean GA: Not reported Rh incompatibility: 2/125 (1.6%)
94
Ref ID: Mean BW: Not reported
Gender M/F: 70/55 G6PD deficiency:

247