Page 301 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type & Patient characteristics Test, Reference Standard, Results Reviewers Comments
Evidence level Threshold for a positive test
> 205 micromol/litre (N = Not reported)
Sensitivity: 75%
Specificity: 72%

Riskin A; Study Type: Full term babies (37–42 weeks) with Visual observation by one of four Correlation of estimated TSB levels with lab Selected population with no
Diagnostic study clinical jaundice in the nursery of a attending neonatologists before TSB (Pearson correlation coefficient) exclusion criterion
Year: 2003 tertiary care hospital. Includes babies discharge of baby from the nursery Test & Reference test described
Evidence Level: with ABO incompatibility and G6PD regarding All physicians (n = 283): in detail
Country: II deficiency. a) Assessment of clinical jaundice r = 0.68, P < 0.001 Test and reference test carried
Israel severe enough to draw blood out within one hour
n = 283 sample Physician 1 (n = 74) Blinding – yes
58 mean age at assessment b) Estimated TSB levels r = 0.79, P < 0.001 Data not extractable for
63.8 ± 21.6 hours calculating TP, FP, TN & FN
Reference standard: Laboratory Physician 2 (n = 62) values
mean GA: 39.5 ± 1.5 weeks TSB levels within 30 mins r = 0.64, P < 0.001
mean BW: 3223 ± 484 g
Gender: Males = 51.2% Physician 3 (n = 69)
r = 0.70, P < 0.001

Ethnicity Physician 4 (n = 78)
Majority reported as Jews (76%) or
Arabs (24%) r = 0.62, P < 0.001

Exclusion: not defined

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