Page 84 - Depression in adults: treatment and management

Depression in adults: treatment and management (NG222)

Other recommendations for research Other recommendations for research

First-line treatment of less severe depression First-line treatment of less severe depression

Is peer support an effective and cost-effective treatment in improving outcomes, including
symptoms, personal and social functioning and quality of life in adults as a stand-alone treatment in
people with less severe depression and as an adjunct to other evidence-based treatments in more

severe depression?

What are the mechanisms of action of effective psychological treatments for acute episodes of
depression in adults? (This question is applicable to less severe and more severe depression.)

For a short explanation of why the committee made these recommendations for research, see
the rationale section on treatment for a new episode of less severe depression.

Full details of the evidence and the committee's discussion are in evidence review B:
treatment of a new episode of depression.

First-line treatment of more severe depression First-line treatment of more severe depression

What is the effectiveness and cost effectiveness of combination treatment with acupuncture and
antidepressants in people with more severe depression in the UK?

For a short explanation of why the committee made these recommendations for research, see
the rationale section on treatment for a new episode of more severe depression.

Full details of the evidence and the committee's discussion are in evidence review B:
treatment of a new episode of depression.

Chronic depression Chronic depression

What is the effectiveness, acceptability and safety of monoamine oxidase inhibitors (MAOIs; for
example, phenelzine) compared to alternative SSRI or SNRI options in treatment-resistant chronic
depression with anhedonia?

How can identifying and focusing on the social determinants of chronic depression, and on the
outcomes that matter to people with depression, enable greater precision for targeting the

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