Page 82 - Depression in adults: treatment and management

Depression in adults: treatment and management (NG222)

Recommendations for research Recommendations for research

The guideline committee has made the following recommendations for research.

Key recommendations for research Key recommendations for research

1 Stopping antidepressants 1 Stopping antidepressants

What is the incidence and severity of withdrawal symptoms for antidepressant medication?

For a short explanation of why the committee made the recommendation for research, see the
rationale section on starting and stopping antidepressants.

For full details of the evidence and the committee's discussion, see the evidence reviews for
the NICE guideline on safe prescribing (evidence review A: patient information and support;
evidence review B: prescribing strategies; evidence review C: safe withdrawal; evidence
review D: withdrawal interventions; evidence review E: monitoring).

Full details of the research recommendation have been added to evidence review B: treatment
of a new episode of depression.

2 Relapse prevention 2 Relapse prevention

What is the effectiveness and cost effectiveness of brief courses of psychological treatment in

preventing relapse for people who have had a successful course of treatment with antidepressants
or psychological therapies but remain at high risk of relapse?

For a short explanation of why the committee made the recommendation for research, see the
rationale section on preventing relapse.

Full details of the evidence and the committee's discussion are in evidence review C:
preventing relapse.

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