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Cell Signalling Biology Michael J. Berridge Module 2 Cell Signalling Pathways 2 41

Module 2: Table inositol lipid kinases and phosphatases
Inositol lipid kinases and phosphatases
Substrate Product Comments
Inositol lipid kinases
Class III PtdIns 3-kinase PtdIns PtdIns3P Also known as hVps34 (Step 1 in
Module 2: Figure phosphoinositide
metabolism). Functions in protein
trafficking (Module 2: Figure
localized inositol lipid signalling)
Phosphatidylinositol 4-kinase (PtdIns Step 2 in Module 2: Figure
4-K) phosphoinositide metabolism.
PtdIns 4-KIIα PtdIns PtdIns4P
PtdIns 4-KIIβ PtdIns PtdIns4P
PtdIns 4-KIIIα PtdIns4P
PtdIns 4-KIIIβ PtdIns4P
Phosphatidylinositol 5-kinase (PtdIns PtdIns PtdIns5P Step 3 in Module 2: Figure
5-K) phosphoinositide metabolism.
Class II PtdIns 3-kinase PtdIns PtdIns3P Step 5 in Module 2: Figure
PtdIns4P PtdIns3,4P 2 phosphoinositide metabolism.
Phosphatidylinositol4P 5-kinase Step 8 in Module 2: Figure
(PtdIns4P 5-K) Type I phosphoinositide metabolism
PtdIns4P 5-KIα PtdIns4P PtdIns4,5P 2 .
PtdIns4P 5-KIβ PtdIns4P PtdIns4,5P 2
PtdIns4P 5-KIγ PtdIns4P PtdIns4,5P 2
PhosphatidylinositolP kinase (PtdInsP PtdIns3P PtdIns3,4P 2 Step 6 in Module 2: Figure
4-K) Type II phosphoinositide metabolism.
PtdIns5P PtdIns4,5P 2
PhosphatidylinositolP 5-kinase PtdIns3P PtdIns3,5P 2 Step 4 in Module 2: Figure
(PIKfyve) Type III phosphoinositide metabolism.
Functions in protein trafficking
(Module 2: Figure localized inositol
lipid signalling). Mutations of this
kinase are associated with
Francois--Neetens mouchetee fleck
corneal dystrophy (CFD)
Class I PtdIns 3-kinases Step 10 in Module 2: Figure
phosphoinositide metabolism.
Class IA PtdIns 3-kinase
p110α (catalytic subunit) PtdIns4,5P 2 PtdIns3,4,5P 3 The structure of these lipid kinases is
shown in Module 2: Figure PI3-K
family
p110β (catalytic subunit) PtdIns4,5P 2 PtdIns3,4,5P 3
p110δ (catalytic subunit) PtdIns4,5P 2 PtdIns3,4,5P 3
p85α (regulatory subunit)
p85β(regulatory subunit)
p55α(regulatory subunit)
p50(regulatory subunit)
p55γ(regulatory subunit)
Class IB PtdIns 3-kinase
p110γ PtdIns4,5P 2 PtdIns3,4,5P 3
p84 (regulatory subunit)
p101 (regulatory subunit)
Class II PtdIns 3-kinase
PtdIns 3KC2α PtdIns4,5P 2 PtdIns3,4,5P 3
PtdIns 3KC2β PtdIns4,5P 2 PtdIns3,4,5P 3
PtdIns 3KC2γ PtdIns4,5P 2 PtdIns3,4,5P 3
Inositol lipid phosphatases
Src homology 2 (SH2) Step 7 in Module 2: Figure
domain-containing inositol phosphoinositide metabolism.
phosphatase (SHIP)
SHIP1 PtdIns3,4,5P 3 PtdIns3,4,P 2
SHIP2 PtdIns3,4,5P 3 PtdIns3,4,P 2
Phosphatase and tensin homologue PtdIns3,4P 2 PtdIns4P Step 9 in Module 2: Figure
deleted on chromosome 10 (PTEN) phosphoinositide metabolism.
This lipid phosphatase is mutated in
PtdIns3,4,5P 3 PtdIns4,5P 2
many human cancers
Myotubularins (MTMR1--MTMR13) Step 11 in Module 2: Figure
phosphoinositide metabolism.
MTM1 PtdIns3 PtdIns Mutations of MTM1 are responsible for
X-linked recessive myotubular
myopathy
MTM2 PtdIns3 PtdIns MTMR2 is mutated in
Charcot--Marie--Tooth disease 4B

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