Page 77 - 51 the significance--29.2_opt
P. 77

59.  Pratley RE, Reusch JE, Fleck PR, Wilson CA, Mekki Q, Alogliptin Study G. Efficacy and
             safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in
             patients with type 2 diabetes: a randomized, double-blind, placebo-controlled
             study. Current medical research and opinion 2009;25(10):2361-71.
          60.  Kaku K, Itayasu T, Hiroi S, Hirayama M, Seino Y. Efficacy and safety of alogliptin added
             to pioglitazone in Japanese patients with type 2 diabetes: a randomized, double-
             blind, placebo-controlled trial with an open-label long-term extension study. Diabetes,
             obesity & metabolism 2011;13(11):1028-35.
          61.  Rosenstock J, Inzucchi SE, Seufert J, Fleck PR, Wilson CA, Mekki Q. Initial combination
             therapy with alogliptin and pioglitazone in drug-naive patients with type 2 diabetes.
             Diabetes care 2010;33(11):2406-8.
          62.  Bosi E, Ellis GC, Wilson CA, Fleck PR. Alogliptin as a third oral antidiabetic drug in
             patients with type 2 diabetes and inadequate glycaemic control on metformin
             and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-
             group study. Diabetes, obesity & metabolism 2011;13(12):1088-96.
          63.  Frederich R, Alexander JH, Fiedorek FT, Donovan M, Berglind N, Harris S, et al. A
             systematic assessment of cardiovascular outcomes in the saxagliptin drug develop-
             ment program for type 2 diabetes. Postgrad Med;122(3):16-27.
          64.  Monami M, Iacomelli I, Marchionni N, Mannucci E. Dipeptydil peptidase-4 inhibitors
             in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc
             Dis;20(4):224-35.
          65.  Williams-Herman D, Engel SS, Round E, Johnson J, Golm GT, Guo H, et al. Safety and
             tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,246
             patients with type 2 diabetes. BMC Endocr Disord;10:7.
          66.  Schweizer A, Dejager S, Foley JE, Couturier A, Ligueros-Saylan M, Kothny W. Assessing
             the cardio-cerebrovascular safety of vildagliptin: meta-analysis of adjudicated
             events from a large Phase III type 2 diabetes population. Diabetes, obesity & meta-
             bolism;12(6):485-94.
          67.  Kahn SE. The relative contribution of insulin resistance and beta-cell dysfunction to
             the pathophysiology of type 2 diabetes. Diabetologia 2003;46:3-19.
          68.  Marchetti P, Dotta F, Lauro D, Purrello F. An overview of pancreatic beta-cell defects
             in human type 2 diabetes: implications for treatment. Regul Pept 2008;146(1-3):4-11.
          69.  Donath MY, Storling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators
             and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med
             2003;81(8):455-70.
          70.  Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and
             increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52(1):
             102-10.
          71.  Drews G, Krippeit-Drews P, Dufer M. Oxidative stress and beta-cell dysfunction.
             Pflugers Arch 2010;460(4):703-18.
          72.  Buchanan TA, Xiang AH, Peters RK, Kjos SL, Marroquin A, Goico J, et al. Preservation
             of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacologi-
             cal treatment of insulin resistance in high-risk hispanic women. Diabetes 2002;51(9):
             2796-803.
          73.  Kitabchi AE, Temprosa M, Knowler WC, Kahn SE, Fowler SE, Haffner SM, et al. Role of
             insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes
             prevention program: effects of lifestyle intervention and metformin. Diabetes 2005;
             54(8):2404-14.
          74.  Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, et al. Dipeptidyl peptidase IV
             inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-
             induced diabetic rats. Diabetes 2003;52(3):741-50.
          75.  Mu J, Woods J, Zhou YP, Roy RS, Li Z, Zycband E, et al. Chronic inhibition of dipeptidyl
             peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and
             function in a rodent model of type 2 diabetes. Diabetes 2006;55(6):1695-704.
          76.  Marchetti P, Lupi R, Del Guerra S, Bugliani M, D’Aleo V, Occhipinti M, et al. Goals
             of treatment for type 2 diabetes: beta-cell preservation for glycemic control.
             Diabetes care 2009;32 Suppl 2:S178-83.
          77.  Ahren B. Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes.
             Expert opinion on emerging drugs 2008;13(4):593-607.
          78.  Havre PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH. The role of CD26/
             dipeptidyl peptidase IV in cancer. Front Biosci 2008;13:1634-45.
          79.  Masur K, Schwartz F, Entschladen F, Niggemann B, Zaenker KS. DPPIV inhibitors extend
             GLP-2 mediated tumour promoting effects on intestinal cancer cells. Regul Pept
             2006;137(3):147-55.

                                          77
   72   73   74   75   76   77   78   79   80   81   82