Page 69 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Table 3. Eligibility criteria for enrollment in protocols with curative intent in chronological order of starting enrollment year
Center, Term used Age Gleason # biopsy PSA Imaging Stage Behavioral indication (other than patients’
Country in original (yr) score cores /% (ng/mL) choice or preference)
[Pubmed ID] article cores

Enrollment
years
Baylor College EM – <7 TRUS – – – Decision for deferred therapy was made by the
of Medicine and /deferred guided patient and treating physician together based on
MSKCC, US 106 therapy sextant the likely presence of small volume cancer.
[15017211] biopsy

1984-2001
McGill Univ., WW; AS – – TRUS – – “Clinically Limited life expectancy because of advanced
Canada 107 guided localized age or poor medical condition
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[18484590] biopsy caner” )

1987-2002
Univ. of AS – – – – – “low-risk Patients who elected WW or AS program. Men
Connecticut disease” on WW were generally older with localized
Health Center, prostate cancer who did not desire aggressive
US 108 intervention. Men on AS were generally younger
[18707696] with low-risk disease.

1990-2006
Four tertiary AS ≤75 ≤6 ≤3 positive ≤10 MRI of the T1-T2a –
care academic cores at prostate was
medical diagnostic selectively
a
canters, US 109 biopsy used at
[19233410] diagnosis

1991-2007
Univ. of Miami, AS; WW 123 ≤80 122 ≤6 110 TRUS guided ≤15 110 – ≤T2/T2b 110 MD influence had the greatest
US 110,122,123 biopsy impact on choosing AS (73%),
[17850361; ≤10 122,123 concerns for incontinence (48%)
20800964; ≤50% of 2 and erectile dysfunction (44%)
21215429] biopsy cores 110 also reasons for choosing AS 122

1991-2007 ≤2 biopsy cores
with ≤20% in
each core 123

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