Page 490 - An Evidence Review of Active Surveillance in Men With Localized Prostate Cancer

Appendix Table C4.2. Comparison between watchful waiting and radical prostatectomy (continued)
Author, Year Study name Comparison Outcome Followup Sample size Results Factors included in the
[Pubmed ID] /Database definition/ (yr) per group model
measurement
Study design instrument
Hadley 207 SEER- RP vs. Death from any Survival RP: 11,936; Unweighted regression PS: age, race/ethnicity,
2010 Medicare conservative cause from was conservative analysis: marital status, tumor
20944078 management Medicare observed management: HR 0.68 (0.63, 0.74); P characteristics, previous
claims. for up to 5879 <0.001 health problems (based
Retrospective 12 years; PS reweighted analysis on NCI combined
cohort mean [calculated using IPTW: HR 0.65 (0.62 comorbidity index and
survival based on the ,0.68); P <0.001 Medicare
free of proportion of PS reweighted analysis reimbursements in the
cancer- patients using SMRW: HR 0.68 12 months before
specific treated with (0.63, 0.75); P <0.001 diagnosis), year of
death = each IV regression using the diagnosis. These
73.2 mo modality, for previous year’s local area variables were included
the overall treatment pattern for in all multivariable
population] conservative management models.
as an instrument:
HR=0.92 (0.39, 2.17); Instrumental variable:
P=0.78 the lagged (previous
year’s) local area
treatment pattern for
conservative
management.
Stattin 223 NPCRSFS RP vs. Death from any Median Surveillance: HR=0.49 (0.41, 0.57) Age at diagnosis,
2010 surveillance cause, data followup 2021 comorbidity,
20562373 obtained from 8.2 yr RP: 3399 socioeconomic group,
the Cause of (IQR=7.1- risk group.
Retrospective Death Register 9.7 yr)
cohort or review of
death
certificates

C-163