Page 213 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type and Patient characteristics Methodology and interventions Results Reviewers Comments
Evidence level
Bruising: OR 4.0 (1.8–8.8)
Cephalohaematoma: OR 3.3 (1.1–10)
Maternal age ≥ 25 years: OR 3.1 (1.2–8.1)
Family history of jaundice: 6.0 (1.0–36.0);
P = 0.05

Risk Index scoring

6 points each for exclusive breastfeeding
and family HISTORY OF jaundice in a
newborn,
4 points each for bruising and Asian race,
3 points each for cephalhematoma and
maternal age ≥ 25 years,
1 point for male sex, -2 points for black
race, and 2(40-GA)

Accuracy of Risk Index score in predicting
significant hyperbilirubinaemia

Overall c-statistic 0.85

Risk index score < 10
+LR: 0.2

Risk index score > 10
+LR: 2.2

Risk index score > 20
+LR: 18.2

Newman TB et al.; Study Type: Cohort of all infants with 1) Frequency of jaundice noted 1) Frequency of jaundice noted in Nested case–control study
Nested case- BW = 2000 g and GA = 36 weeks in the medical record in term and newborns within 24 hours of age (Kaplan
Year: 2002 control study born alive at 12 hospitals of a near-term newborns less than Meier survival estimates + no. with TSB Some cases were included in 42290 –
health maintenance organisation 24 hours old measured) should we excluded 42290
Country: USA Evidence Level: II during a four year period
(n = 105 384) Cases and controls taken from comparable
10 2) Association of jaundice noted Less than 18 hours of age populations but exclusion criteria not well
Cases: Babies with maximum TSB in the first 24 hours after birth 3.8% defined
levels = 428 micromol/litre within with the use of phototherapy and Confounding variables controlled
the first 30 days after birth risk of developing Less than 24 hours of age Methodology described adequately but
6.7%
hyperbilirubinaemia after
(n = 140) controlling for confounding exact number of babies with jaundice
variables - 2) Association of jaundice noted within noted in first 24 hours calculated with
Controls: Random sample of Kaplan Meier analysis
babies from the cohort with 24 hours of age with risk factors (results of
maximum TSB bivariate analysis)
levels = 428 micromol/litre
(n = 631) No statistically significant difference

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