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NEUROSCIENCE OF PSYCHOACTIVE SUBSTANCE USE AND DEPENDENCE




                     The use of pharmacotherapies and drug immunotherapies under legal
                   coercion is likely to be contentious. It is an arguably ethical policy if the
                   process is under judicial oversight and if offenders are offered constrained
                   choices of whether or not to accept treatment, and of the type of treatment
                   that they accept. Any coerced use of a cocaine immunotherapy should be
                   done cautiously and only after considerable clinical experience of its use with
                   voluntary patients. It should be trialed, and its safety, effectiveness and cost-
                   effectiveness should be rigorously evaluated. Such an evaluation also needs
                   to examine any adverse social or ethical consequences.


                   References
                   Adler MW (1995) Human subject issues in drug abuse research: college on
                   problems of drug dependence. Drug and Alcohol Dependence, 37:167–175.
                   Alves WA, Macciocchi SN (1996) Ethical considerations in clinical neuroscience:
                   current concepts in neuroclinical trials. Stroke, 27:1903–1909.
                   American Psychological Association Science Directorate (2001) Research with
                   animals in psychology. Washington, DC, American Psychological Association.
                   Andrews G, Henderson S, Hall W (2001) Prevalence, comorbidity, disability and
                   service utilisation: overview of the Australian national mental health survey.
                   British Journal of Psychiatry, 178:145–153.
                   Anon (2001) The tightening grip of big pharma. Lancet, 357:1141.
                   Anthony JC, Helzer J (1991) Syndromes of drug abuse and dependence. In: Robins
                   LN, Regier DA, eds. Psychiatric disorders in America. New York, NY, Academic
                   Press:116–154.
                   Ashcroft R (2001) Selection of human research subjects. In: Chadwick R, Ed. The
                   concise encyclopedia of the ethics of new technologies. New York, NY, Academic
                   Press:255–266.
                   Beauchamp TL, Childress JF (2001) Principles of biomedical ethics. Oxford, Oxford
                   University Press.
                   Brody BA (1998) The ethics of biomedical research: an international perspective.
                   Oxford, Oxford University Press.
                   Carrera MR et al. (1995) Suppression of psychoactive effects of cocaine by active
                   immunization. Nature, 378:727–730.
                   Carrera MR et al. (2000) Cocaine vaccines: antibody protection against relapse
                   in a rat model. Proceedings of the National Academy of Sciences of the United States
                   of America, 97:6202–6206.
                   Cochrane AL (1972) Effectiveness and efficiency: random reflections on health
                   services. Abingdon, Berkshire, Nuffield Provincial Hospitals Trust.
                   Cohen PJ (1997) Immunization for prevention and treatment of cocaine abuse:
                   legal and ethical implications. Drug and Alcohol Dependence, 48:167–174.
                   Cohen PJ (2000) No more kicks. New Scientist, 166:23–36.


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