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ANNEX 3. Pharmacology of antimalarial medicines
36. Kissinger E et al. Clinical and neurophysiological study of the effects of multiple doses of
artemisinin on brain-stem function in Vietnamese patients. American Journal of Tropical
Medicine and Hygiene, 2000, 63:48–55.
37. Hien TT et al. Neuropathological assessment of artemether-treated severe malaria. Lancet,
2003, 362:295–296.
37a. Assessment of the safety of artemisinin compounds in pregnancy. Geneva, World Helath
Organization, 2003 (document WHO/CDS/MAL/2003.1094)
38. Ezzet F, Mull R, Karbwang J. Population pharmacokinetics and therapeutic response of
CGP 56697 (artemether + benflumetol) in malaria patients. British Journal of Clinical
Pharmacology, 1998, 46:553–561. A3
39. Murphy SA et al. The disposition of intramuscular artemether in children with cerebral
malaria; a preliminary study. Transactions of the Royal Society of Tropical Medicine and
Hygiene, 1997, 91:331–334.
40. Hien TT et al. Comparative pharmacokinetics of intramuscular artesunate and artemether
in patients with severe falciparum malaria. Antimicrobial Agents and Chemotherapy, 2004,
48:4234–4239.
41. Mithwani S et al. Population pharmacokinetics of artemether and dihydroartemisinin
following single intramuscular dosing of artemether in African children with severe
falciparum malaria. British Journal of Clinical Pharmacology, 2004, 57:146–152.
42. Brewer TG et al. Neurotoxicity in animals due to arteether and artemether. Transactions
of the Royal Society of Tropical Medicine and Hygiene, 1994, 88 (Suppl. 1):S33–36.
43. Bethell DB et al. Pharmacokinetics of oral artesunate in children with moderately severe
Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine
and Hygiene, 1997, 91:195–198.
44. Batty KT et al. A pharmacokinetic and pharmacodynamic study of intravenous vs oral
artesunate in uncomplicated falciparum malaria. British Journal of Clinical Pharmacology,
1998, 45:123–129.
45. Newton PN et al. Antimalarial bioavailability and disposition of artesunate in acute
falciparum malaria. Antimicrobial Agents and Chemotherapy, 2000, 44:972–997.
46. Krishna S et al. Bioavailability and preliminary clinical efficacy of intrarectal artesunate
in Ghanaian children with moderate malaria. Antimicrobial Agents and Chemotherapy,
2001, 45:509–516.
47. Ilett KF et al. The pharmacokinetic properties of intramuscular artesunate and rectal
dihydroartemisinin in uncomplicated falciparum malaria. British Journal of Clinical
Pharmacology, 2002, 53:23–30.
48. Newton PN et al. Comparison of oral artesunate and dihydroartemisinin antimalarial
bioavailabilities in acute falciparum malaria. Antimicrobial Agents and Chemotherapy,
2002, 46:1125–1127.
49. White NJ, van Vugt M, Ezzet F. Clinical pharmacokinetics and pharmacodynamics of
artemether-lumefantrine. Clinical Pharmacokinetics, 1999, 37:105–125.
50. van Vugt M et al. No evidence of cardiotoxicity during antimalarial treatment with
artemether-lumefantrine. American Journal of Tropical Medicine and Hygiene, 1999,
61:964–967.
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