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ANNEX 3. Pharmacology of antimalarial medicines



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                Organization, 2003 (document WHO/CDS/MAL/2003.1094)
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                Pharmacology, 1998, 46:553–561.                                        A3
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           40.  Hien TT et al. Comparative pharmacokinetics of intramuscular artesunate and artemether
                in patients with severe falciparum malaria. Antimicrobial Agents and Chemotherapy, 2004,
                48:4234–4239.
           41.   Mithwani S et al. Population pharmacokinetics of artemether and dihydroartemisinin
                following single intramuscular dosing of artemether in African children with severe
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                Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine
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           44.  Batty KT et al. A pharmacokinetic and pharmacodynamic study of intravenous vs oral
                artesunate in uncomplicated falciparum malaria. British Journal of Clinical Pharmacology,
                1998, 45:123–129.
           45.  Newton PN et al. Antimalarial bioavailability and disposition of artesunate in acute
                falciparum malaria. Antimicrobial Agents and Chemotherapy, 2000, 44:972–997.
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                in Ghanaian children with moderate malaria. Antimicrobial Agents and Chemotherapy,
                2001, 45:509–516.
           47.   Ilett KF et al. The pharmacokinetic properties of intramuscular artesunate and rectal
                dihydroartemisinin in uncomplicated falciparum malaria. British Journal of Clinical
                Pharmacology, 2002, 53:23–30.
           48.  Newton PN et al. Comparison of oral artesunate and dihydroartemisinin antimalarial
                bioavailabilities in acute falciparum malaria. Antimicrobial Agents and Chemotherapy,
                2002, 46:1125–1127.
           49.   White NJ, van Vugt M, Ezzet F. Clinical pharmacokinetics and pharmacodynamics of
                artemether-lumefantrine. Clinical Pharmacokinetics, 1999, 37:105–125.
           50.  van Vugt M et al. No evidence of cardiotoxicity during antimalarial treatment with
                artemether-lumefantrine. American Journal of Tropical Medicine and Hygiene, 1999,
                61:964–967.
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