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or other moist areas of the body; peeling skin that results in painful
sores; and fever, headache, and other flu-like symptoms. Internal
organs may also be affected. SJS may occur as a severe reaction
to certain drugs, including NNRTIs used to treat HIV infection.
STI
An abbreviation used for either structured treatment interruption or
for sexually transmitted infection (also known as sexually transmitted
disease, or STD).
See Also: Structured Treatment Interruption (STI)
Sexually Transmitted Disease (STD)
Stomatitis
Inflammation or irritation of the mucous membranes in the mouth.
Strain
A type of virus that has a common ancestry but also clear-cut
physiologic distinctions, often in resistance profiles. For example,
HIV molecules that express nucleoside-associated resistance
mutations are a separate viral strain than wild-type HIV molecules,
which do not express resistance mutations.
Structured Intermittent Therapy (SIT)
A type of structured treatment interruption that is characterized
by time-based treatment cycles (weeks or months on and off
anti-HIV drugs).
See Also: Structured Treatment Interruption (STI)
S
Structured Treatment Interruption (STI)
Also known as a drug holiday. A planned, doctor-supervised
discontinuation of anti-HIV drugs. Goals of STI include reduced
toxicity, reduced treatment costs, and improved quality of life.
Subclinical Infection
An infection or phase of an infection without obvious symptoms or
signs of disease.
126 HIV/AIDS Glossary