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Table 8. Antiretroviral Regimens or Components That Should Not Be Offered At Any Time (page 2 of 2)

Rationale Exception
NVP in ARV-naive women with CD4 • High incidence of symptomatic hepatotoxicity • If no other ARV option available; if
3
count >250 cells/mm or men with used, patient should be closely
3
CD4 count >400 cells/mm (BI) monitored
d4T + ZDV (AII) • Antagonistic effect on HIV-1 • No exception
Unboosted DRV, SQV, or TPV (AII) • Inadequate bioavailability • No exception

Acronyms: 3TC = lamivudine, ABC = abacavir, ATV = atazanavir, d4T = stavudine, ddI = didanosine, DRV = darunavir, EFV = efavirenz, ETR =
etravirine, FPV = fosamprenavir, FTC = emitricitabine, IDV = indinavir, NVP = nevirapine, RTV = ritonavir, SQV = saquinavir, TDF = tenofovir,
TPV = tipranavir, ZDV = zidovudine

References

1. Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for
use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal
HIV transmission in the United States. May 24, 2010:1-117. http://aidsinfo.nih.gov/contentfiles/PerinatalGL.pdf.
2. Delfraissy JF, Flandre P, Delaugerre C, et al. Lopinavir/ritonavir monotherapy or plus zidovudine and lamivudine in
antiretroviral-naive HIV-infected patients. AIDS. 2008;22(3):385-393.
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patients with HIV RNA below 50 copies/ml. AIDS. 2010;24(2):223-230.
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6. Hirsch M, Steigbigel R, Staszewski S, et al. A randomized, controlled trial of indinavir, zidovudine, and lamivudine in
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8. Bartlett JA, Johnson J, Herrera G, et al. Long-term results of initial therapy with abacavir and lamivudine combined with
efavirenz, amprenavir/ritonavir, or stavudine. J Acquir Immune Defic Syndr. 2006;43(3):284-292.
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10. Moore RD, Wong WM, Keruly JC, et al. Incidence of neuropathy in HIV-infected patients on monotherapy versus those
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Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents G-4

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