Page 210 - HIV/AIDS Guidelines

Table 16a. Interactions Among Protease Inhibitors*

*NFV and IDV are not included in this table. Please refer to NFV and IDV FDA package inserts for information regarding NFV and IDV drug
interactions.

Drug
ATV FPV LPV/r RTV SQV TPV
Affected
DRV Dose: ATV 300 mg No data Should not be Dose: (DRV 600 mg Should not be No data
once daily + DRV coadministered + RTV 100 mg) BID coadministered
600 mg BID + RTV because doses are or (DRV 800 mg + because doses
100 mg BID not established RTV 100 mg) once are not
daily established

FPV Dose: Insufficient Should not be Dose: (FPV 1400 Dose: Insufficient Should not be
data coadministered mg + RTV 100 mg data coadministered
because doses are or because doses
•
not established 200 mg) once daily; are not
or (FPV 700 mg + established
RTV 100 mg) BID
LPV/r Dose: ATV 300 mg Should not be LPV is Dose: SQV 1000 Should not be
once daily + LPV/r coadministered coformulated with mg BID + LPV/r coadministered
400/100 mg BID because doses are • RTV as Kaletra. 400/100 mg BID because doses
not established are not
established
RTV Dose: (ATV 300 mg Dose: (FPV 1400 LPV is Dose: (SQV 1000 Dose: (TPV 500
+ RTV 100 mg) mg + RTV 100 mg coformulated with mg + RTV 100 mg) mg + RTV 200
once daily or 200 mg) once RTV and marketed • BID mg) BID
daily; or (FPV 700 as Kaletra.
mg + RTV 100 mg)
BID
SQV Dose: Insufficient Dose: Insufficient Dose: SQV 1000 Dose: (SQV 1000 Should not be
data data mg BID + LPV/r mg + RTV 100 mg) coadministered
400/100 mg BID BID • because doses
are not
established

Key to Abbreviations: ATV = atazanavir, BID = twice daily, DRV = darunavir, FDA = Food and Drug Administration, FPV = fosamprenavir,
IDV = indinavir, LPV/r = lopinavir/ritonavir, NFV = nelfinavir, PI = protease inhibitor, RTV = ritonavir, SQV = saquinavir, TPV = tipranavir

Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents K-40

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