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Table 3. Laboratory Monitoring Schedule for Patients Prior to and After Initiation of
            Antiretroviral Therapy


                                                 2–8 weeks
                    Entry Follow-up     ART       post-ART   Every 3–6   Every 6    Every 12    Treatment   Clinically
                     into   before   initiation or
                     care    ART    modification a initiation or  months  months    months       failure   indicated
                                                modification
         CD4 count    √    every 3–6     √                       √       In clinically stable patients  √      √
                            months                                      with suppressed viral load,
                                                                        CD4 count can be monitored
                                                                           every 6–12 months
                                                                               (see text)
         Viral load   √    every 3–6     √           √ b         √ c                               √           √
                            months

         Resistance   √                  √ d                                                       √           √
         testing
         HLA-B*5701                      √
         testing                     if considering
                                        ABC
         Tropism                         √                                                         √           √
         testing                    if considering a                                          if considering a
                                        CCR5                                                  CCR5 antagonist
                                      antagonist                                               or for failure of
                                                                                                  CCR5
                                                                                              antagonist-based
                                                                                                 regimen
         Hepatitis B  √                  √                                                                     √
         serology e                  may repeat if
                                     HBsAg (-) and
                                     HBsAb (-) at
                                       baseline
         Basic        √    every 6–12    √           √           √                                             √
         chemistry f        months
         ALT, AST, T.  √   every 6–12    √           √           √                                             √
         bilirubin          months
         CBC with     √    every 3–6     √           √           √                                             √
         differential       months                 if on ZDV
         Fasting lipid  √  if normal,    √           √                      √          √                       √
         profile            annually             consider 4–8           if abnormal at  if normal at
                                                  weeks after              last       last
                                                  starting new          measurement measurement
                                                    ART
         Fasting      √    if normal,    √                       √          √                                  √
         glucose            annually                         if abnormal at  if normal at
                                                                last       last
                                                             measurement measurement
         Urinalysis g  √                 √                                  √          √                       √
                                                                         if on TDF h
         Pregnancy                       √                                                                     √
         test                        if starting EFV





            Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents         C-2

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