Page 187 - HIV/AIDS Guidelines

Table 14. Drugs That Should Not Be Used With Protease Inhibitors, Non-Nucleoside Reverse
Transcriptase Inhibitors, or CCR5 Antagonist (page 1 of 2)

This table lists only drugs that should not be coadministered at any dose and regardless of RTV boosting. See Tables 15 and
16 for more detailed PK interaction data.

Drug Categories

Lipid- Gastro- Ergot
Antiretroviral Cardiac Antimyco- Neuro- Psycho- Antiretroviral
Agents a,b Agents Lowering bacterials intestinal leptics tropics Derivatives Herbs Agents Others
Agents Drugs (vasoconstrictors)
ATV +/− RTV none lovastatin rifampin cisapride e pimozide midazolam f dihydroergotamine St. ETR alfuzosin
simvastatin rifapentine c triazolam ergonovine John’s NVP irinotecan
ergotamine wort salmeterol
methylergonovine sildenafil for PAH
DRV/r none lovastatin rifampin cisapride e pimozide midazolam f dihydroergotamine St. none alfuzosin
simvastatin rifapentine c triazolam ergonovine John’s salmeterol
ergotamine wort sildenafil for PAH
methylergonovine
FPV +/− RTV flecainide lovastatin rifampin cisapride e pimozide midazolam f dihydroergotamine St. ETR alfuzosin
propafenone simvastatin rifapentine c triazolam ergonovine John’s salmeterol
ergotamine wort sildenafil for PAH
methylergonovine
LPV/r none lovastatin rifampin d cisapride e pimozide midazolam f dihydroergotamine St. none alfuzosin
simvastatin rifapentine c triazolam ergonovine John’s salmeterol
ergotamine wort sildenafil for PAH
methylergonovine
SQV/r amiodarone lovastatin rifampin d cisapride e pimozide midazolam f dihydroergotamine St. none alfuzosin
dofetilide simvastatin rifapentine c triazolam ergonovine John’s salmeterol
flecainide trazodone ergotamine wort sildenafil for PAH
lidocaine methylergonovine garlic
propafenone supple-
quinidine ments
TPV/r amiodarone lovastatin rifampin cisapride e pimozide midazolam f dihydroergotamine St. ETR alfuzosin
flecainide simvastatin rifapentine c triazolam ergonovine John’s salmeterol
propafenone ergotamine wort sildenafil for PAH
quinidine methylergonovine
EFV none none rifapentine c cisapride e pimozide midazolam f dihydroergotamine St. other NNRTIs none
triazolam ergonovine John’s
ergotamine wort
methylergonovine
ETR none none rifampin none none none none St unboosted PIs carbamazepine
rifapentine c John’s ATV/r, FPV/r, phenobarbital
wort or TPV/r phenytoin
other NNRTIs clopidogrel
NVP none none rifapentine c none none none none St. ATV +/− RTV ketoconazole
John’s other
wort NNRTIs
RPV none none rifabutin proton none none none St. other NNRTIs carbamazepine
rifampin pump John’s oxcarbazepine
rifapentine c inhibitors wort phenobarbital
phenytoin
MVC none none rifapentine c none none none none St. none none
John’s
wort

Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents K-17

Downloaded from http://aidsinfo.nih.gov/guidelines on 12/8/2012 EST.