Page 299 - Drug Class Review

Drug Effectiveness Review Project
Alzheimer classification: Mild-moderate
Groups similar at baseline: Yes

Health Outcome Measures: NR 0.013)

tacrine placebo 73 76 62 66 NR NR 17.7 16.8 Primary Outcome Measures: MMSE; CGRS Secondary Outcome Measures: RGRS; GBS; ADAS-Noncog Timing of assessments: Baseline and weeks 4, 8 and 12 Intermediate Outcome Measures: No significant differences in MMSE scores between groups (P = 0.55) CGRS and RGRS scores significantly better in TAC compared to placebo (P = 0.012 and P = Page 180 of 205

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Final Report Update 1 Authors: Wood et al. Year: 1994 POPULATION CHARACTERISTICS: Mean age (years): Sex (% female): Ethnicity: Other germane population qualities: MMSE • OUTCOME ASSESSMENT: RESULTS: Alzheimer's Drugs