Page 201 - Drug Class Review
P. 201

Drug Effectiveness Review Project











                          Alzheimer Drugs      Authors:  Seltzer et al. 46     Year:  2004   Country: US   Eisai Inc. and Pfizer Inc.     To evaluate the efficiency of donepezil treatment in early stage Alzheimer’s Disease   Study design: RCT  Setting: Multi-center (17 sites)   Sample size: 153      placebo   donepezil      N/A  5-10 mg/d   24 weeks   24 weeks   57   96  Generally healthy ambulatory patients aged 50-92 years; diagnosis of probable AD within the past 12  months; modified Hachinski Ischemia Scale score of 4 or less; Global Dementia Rating score of 0.5 or  1.0; MMSE score of 21-26; mild impairment in activities




























             Final Report Update 1     Efficacy/Effectiveness      STUDY:      FUNDING:   RESEARCH OBJECTIVE:      DESIGN:           INTERVENTION:    Dose:     Duration:     Sample size:   INCLUSION:   EXCLUSION:   OTHER MEDICATIONS/  INTERVENTIONS ALLOWED:     Alzheimer's Drugs
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