Page 194 - Drug Class Review
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Page 127 of 205
Drug Effectiveness Review Project
placebo NR NR NR 23.29 54.1
rivastigmine 6-12 mg/d NR NR NR 23.57 55.22 Timing of assessments: Primary outcome measures at baseline and weeks 12, 18 and 26; secondary Scores on PDS improved in patients taking high dose RIV when compared with placebo, P < 0.05 (LOCF analysis); no significant difference observed between low dose RIV and placebo, P > PDS scores significantly more improved for high dose RIV compared to placebo (P < 0.05) but Scores on ADAS-Cog improved in patients taking high dose RIV (6-12 mg/d) when compared with placebo, P < 0.05 (LOCF analysis); no significant difference obser
Alzheimer classification: Mild to moderately severe
Groups similar at baseline: Yes
rivastigmine 1-4 mg/d NR NR NR 23.87 53.8 Primary Outcome Measures: ADAS-Cog; PDS; CIBIC Secondary Outcome Measures: MMSE; GDS outcome measures at baseline and week 26 Health Outcome Measures: 0.05* not for low dose RIV Intermediate Outcome Measures: RIV (1-4 mg/d) and placebo, P > 0.05* not for low dose RIV
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Final Report Update 1 Authors: Rösler et al. Year: 1999 POPULATION CHARACTERISTICS: Mean age (years): Sex (% female): Ethnicity: Other germane population qualities: Baseline ADAS-Cog • Baseline PDS • OUTCOME ASSESSMENT: RESULTS: Alzheimer's Drugs