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Appendix I: Search strategies



                   2  controlled clinical trial.pt.                                                75338
                   3  DOUBLE BLIND METHOD/                                                         81099
                   4  SINGLE BLIND METHOD/                                                         7643
                   5  RANDOM ALLOCATION/                                                           20221
                   6  RANDOMIZED CONTROLLED TRIALS/                                                0
                   7  or/1-6                                                                       317038
                   8  ((single or double or triple or treble) adj5 (blind$ or mask$)).tw,sh.       106559
                   9  clinical trial.pt.                                                           273458
                   10 exp CLINICAL TRIAL/                                                          0
                   11 exp CLINICAL TRIALS AS TOPIC/                                                0
                   12 (clinic$ adj5 trial$).tw,sh.                                                 35204
                   13 PLACEBOS/                                                                    18244
                   14 placebo$.tw,sh.                                                              105601
                   15 random$.tw,sh.                                                               241696
                   16 or/8-15                                                                      386437
                   17 or/7,16                                                                      397360
                   18 META ANALYSIS/                                                               0
                   19 META ANALYSIS AS TOPIC/                                                      171
                   20 meta analysis.pt.                                                            476
                   21 (metaanaly$ or meta-analy$ or (meta adj analy$)).tw,sh.                      1056
                   22 (systematic$ adj5 (review$ or overview$)).tw,sh.                             250
                   23 (methodologic$ adj5 (review$ or overview$)).tw,sh.                           26
                   24 or/18-23                                                                     1452
                   25 review$.pt.                                                                  2654
                      (medline or medlars or embase or cinahl or cochrane or psycinfo or psychinfo or psychlit
                   26                                                                              406
                      or psyclit or "web of science" or "science citation" or scisearch).tw.
                   27 ((hand or manual$) adj2 search$).tw.                                         38
                      (electronic database$ or bibliographic database$ or computeri?ed database$ or online
                   28                                                                              61
                      database$).tw,sh.
                   29 (pooling or pooled or mantel haenszel).tw,sh.                                2046
                   30 (peto or dersimonian or der simonian or fixed effect).tw,sh.                 31
                   31 or/26-30                                                                     2491
                   32 and/25,31                                                                    93
                   33 or/24,32                                                                     1515
                   34 letter.pt.                                                                   4483
                   35 case report.tw.                                                              149
                   36 comment.pt.                                                                  1562
                   37 editorial.pt.                                                                280
                   38 historical article.pt.                                                       58
                   39 or/34-38                                                                     5258
                   40 17 not 39                                                                    392251
                   41 33 not 39                                                                    1481
                   42 or/40-41                                                                     392505





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