Page 236 - 16Neonatal Jaundice_compressed

Appendix H: Evidence tables

Bibliographic details Study type and Patient characteristics Methodology and interventions Results Reviewers Comments
Evidence level
Gender: Not reported Neurodevelopmental variables showed that various demographic and
Ethnicity: Not reported were clinical variables
Psychomotor were associated with poor
Peak bilirubin levels that were Developmental Index (PDI) < 70 neurodevelopmental outcomes.
recorded beyond the first 14 days Mental Developmental After adjustment for these risk factor,
of life were excluded. Index (MDI) < 70 significant
moderate or severe cerebral association were found between peak TSB
palsy and
hearing impairment (hearing death or NDI - OR 1.068 (95% CI 1.03–
aids), 1.11)
composite category designated as PDI < 70 - OR1.057 (95% CI 1.00–1.12)
neuro-developmental impairment hearing impairment requiring hearing aids
(NDI). OR 1138 (95% CI 1.00–1.30)

The NDI is defined as infants There was no significant association
with any 1 or more of the between peak TSB and other variables
following:
PDI < 70,
MDI < 70,
moderate to severe cerebral palsy
bilateral blindness,
bilateral hearing impairment
requiring amplification.

Maisels MJ et al.; Study Type: From a cohort of 11 456 infants, Demographic and clinical risk 11.456 infants survived at discharge, 75
Retrospective 75 infants who following factors and serum bilirubin levels were readmitted with TSB
Year:2009 nested- case– discharge, had been readmitted were analysed in terms of > 291 micromol/litre.
control study with hyperbilirubinaemia (TSB readmittance for
Country: USA > 291 micromol/litre) were hyperbilirubinaemia The step-wise logistic regression analysis
Evidence Level: II compared with 75 matched showed that various demographic and
17 controls. Factors include clinical variables were associated with
readmission for hyperbilirubinaemia
Hyperbilirubinaemia group Maternal age
n = 75 Gestational age After adjustment for these risk factor,
mean BW: Not reported Ethnicity significant association were found between
mean GA: Not reported Mode of delivery TSB > 291 micromol/litre
Gender: Males 59% Gender and
Ethnicity: Feeding Gestation age
White: 77% TCB percentile 35 to 36 6/7 weeks Adj OR 20.79 2.34,
Asian: 12% Bruising/cephalohaematoma 184.74)
st
Black: 1% Jaundice in 1 24 hours 37 to 37 6/7 weeks Adj OR 14.86 (1.91,
Other: 10% Length of stay after birth 115.38)
.
Control group Feeding
n = 75 Breast only adj OR 10.75 (2.37, 48.82)
mean BW: Not reported
mean GA: Not reported TCB > 95%centile
Gender: Males 52% Adj OR 149.89 (20.41, > 999.99)

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