Page 21 - AIDSBK23C

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these regions and appear to be transmitted more efficiently than the subtype B, which is more
common to developed nations of Europe and North America. The more virulent subtype C
accounts for half of all new infections. The evolutionary changes in HIV accounting for
differences in subtype transmission have included env gene mediated receptor affinity and LTR
and tat gene mediated transcriptional activation.[100]

Subtypes of HIV-1
Group M

Subtype A East and Central Africa; Central Asia; Eastern Europe
Subtype AE Southeast Asia
Subtype AG West Africa
Subtype B Americas; Western Europe; East Asia; Oceania
Subtype C India; Southern and Eastern Africa
Subtype D East Africa
Subtype G West Africa
Subtype H Central Africa
Subtype J Central America
Subtypes F, H, J, K Variable

Group N Cameroun
Group O West Africa
Group P Cameroun