Page 38 - Cardiac testing for coronary artery disease in potential kidney transplant recipients

C H A R A C T E R I S T I C S O F S T U D I E S

Characteristics of included studies [ordered by study ID]

Bates 1996

Clinical features and settings Clinical features
• Adult patients who developed insulin dependent DM aged ≤ 25 years and
underwent DSE before planned kidney or kidney-pancreas transplantation between
January 1989 and July 1993.
Setting
• University Hospital, Indianapolis, Indiana, USA.

Participants • Number: 53 patients had preoperative screening; 17 received both DSE and
coronary angiography
• DM: 100%
• Angina pectoris: Not reported
• Hypertension: 98%
• Sex: 64% male

Study design Prospective, cohort study

Target condition and reference standard(s) CAD on coronary angiography
• defined by ≥ 50% stenosis

Index and comparator tests DSE
• Regional wall motion was graded as normal, hypokinetic, akinetic, or dyskinetic
using a 16-segment model at rest, low dose, peak dose, and recovery stages, and assigned
a coronary vascular distribution. A study was considered abnormal if a wall motion
abnormality involving ≥ 2 segments was present at rest or developed during stress.

Follow-up Patients were followed-up for a mean of 498 ± 425 days (range 2 to 1269) after trans-
plantation

Notes

Table of Methodological Quality

Item Authors’ judgement Description

Representative spectrum? Yes Adult patients with insulin-dependent DM
All tests being considered for kidney and/or kidney-
pancreas transplantation

Acceptable reference standard? Yes Coronary angiography with a reference
All tests standard threshold ≥ 50% stenosis

Acceptable delay between tests? No 18 patients underwent cardiac catheterisa-
All tests tion within 101 ± 263 days (range = 200
days before to 557 days after) of DSE. In-

Cardiac testing for coronary artery disease in potential kidney transplant recipients (Review) 36
Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.