Page 6 - Screening for Cervical Cancer: Systematic Evidence Review

Table of Contents

Screening History and Interval ..............................................................................43
Screening among Women Who Have Had a Hysterectomy..................................44
Summary................................................................................................................45
Key Question 2 ..................................................................................................................46
New Methods for Preparing or Evaluating Cervical Cytology..............................46
Neural-network Rescreening .................................................................................50
Computerized Rescreening....................................................................................53
Harms.....................................................................................................................54
Benefits ..................................................................................................................54
Costs.......................................................................................................................55
Summary................................................................................................................57
Key Question 3: Role of HPV Testing in Cervical Cancer Screening .............................58
Screening Use of HPV Testing..............................................................................59
HPV Screening for Detection of High-grade Cervical Changes ...........................60
HPV Screening for Detection of Low-Grade Cervical Changes ...........................61
Triage USE of HPV Testing ..............................................................................................62
Benefits ..................................................................................................................65
Risks.......................................................................................................................66
Costs.......................................................................................................................66

IV. Discussion..........................................................................................................................75
Context...............................................................................................................................75
Major Findings and Limitations of the Literature..............................................................76
Who Should be Screened and How Often?............................................................76
New Methods for Preparing or Evaluating Cervical Cytology..........................................78
The Role of HPV Testing in Cervical Cancer Screening and Triage ................................79
Benefits and Harms............................................................................................................80
Future Research Needs ......................................................................................................81

References ................................................................................................................................83

List of Appendices

Appendix A. Acknowledgments............................................................................................... A-1
Appendix B. Methods................................................................................................................B-1
Appendix C. Evidence Tables...................................................................................................C-1

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