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3. Electrodiagnostic studies indicative of a polyneuropathy with features of
both axonal loss and demyelination.
4. Normal CSF cell count and only minimal, if any, elevation of protein, with
negative VDRL.
5. No other etiology (including toxic exposure to dideoxyinosine). Nerve
biopsy may be indicated to rule out certain etiologies such as amyloid, but
is not a requirement.
POSSIBLE (must have each of the following):
1. Other potential etiology present (must have each of the following):
a. As above (see Probable) #1, #2, and #3.
b. Other potential etiology is present and the cause is uncertain.
2. Incomplete clinical evaluation (must have each of the following):
a. As above (see Probable) #1 and #2.
b. Etiology cannot be determined (appropriate laboratory
investigations not performed).
III. HIV-1-associated myopathy
PROBABLE (must have each of the following:
1. Symptoms of proximal lower and/or upper extremity weakness,
documented by physical examination.
2. No other etiology (including toxic exposure to zidovudine).
Electromyography (EMG) and muscle biopsy may be necessary to rule
out certain other etiologies.
POSSIBLE (must have each of the following):
1. Other potential etiology present (must have each of the following):
a. As above (see Probable) #1.
b. Other potential etiology is present and the cause is uncertain.
2. Incomplete clinical evaluation (must have each of the following):
a. As above (see Probable) #1.
b. Etiology cannot be determined (appropriate laboratory
investigations not performed).
